Work

Advances in Understanding the Impact of Human Gut Microbiota on Chemotherapy-Induced Neutropenia

Year: 2025

Type: article

Abstract: Neutrophils play a crucial role in defending against bacterial and fungal pathogens; however, chemotherapy reduces neutrophil counts, increasing infection risk and worsening cancer treatment outcomes. Emerging evidence highlights the gut microbiota as a promising biomarker and therapeutic target for chemotherapy-induced neutropenia (CIN). Here, we review current knowledge regarding the relationship between the gut microbiota and CIN, summarizing the mechanisms by which the microbiota influence neutrophil dynamics, current therapeutic approaches, and limitations in regard to preserving microbiota stability. This review offers a theoretical foundation for "gut-protective" chemotherapy, potentially facilitating personalized treatments, although clinical translation remains challenging.

Source: Biomedicines

DOI: 10.3390/biomedicines14010055

Authors: Mengyuan He, Liangkang Lin, Cheng Ouyang, Su Liu, Chun Chen

Institution: The Seventh Affiliated Hospital of Sun Yat-sen University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137