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Comparison of three PEG precipitation protocols for the detection of macrovitamin B12 interference

Year: 2025

Type: conference-abstract

Abstract: The presence of macrovitamin B12 (macroB12) in serum inferfers in result interpretation of total vitamin B12 (B12) result and can lead to misidentification of deficiency. Polyethylene glycol (PEG) precipitation is a non-specific method that removes macromolecules (protein polymers and antibody-bound analytes) allowing measurment of circulating vitamin B12 (i.e. B12 bound to transcobalamin and haptocorrin).

Source: ORBi (University of Liège)

Authors: Vranken, Laura, DIEUPE, Grace, Cavalier, Etienne

Institution: Centre Hospitalier Universitaire de Liège

Language: English

Topic: Clinical Laboratory Practices and Quality Control

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7117521845

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