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Effects of Dietary Supplementation with Coriander Seed Powder on Serum Lipid Profile, Glycemic Indices, and Oxidative Stress Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: This study aimed to investigate the effects of coriander seed supplementation on serum lipid profiles, glycemic indices, and oxidative stress biomarkers in patients with type 2 diabetes mellitus (T2DM).In total, 40 such patients aged 30-60 years were allocated into two groups receiving either coriander seed powder (1,000 mg/d, n=20) or placebo (1,000 mg/d, n=20) for 6 weeks.Serum lipid profile: total cholesterol (TC), high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol (LDL-C), and triglycerides (TGs); anthropometric measurements; dietary intake; and biochemical parameters including fasting blood serum (FBS), serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and malondialdehyde (MDA); and total antioxidant capacity (TAC) were assessed before and after supplementation.Coriander seed powder markedly reduced the FBS (156.15±23.19 to 130.30±21.15mg/dL), serum insulin (17.72±0.47 to 17.12±0.76U/mL), HOMA-IR (6.82±0.95 to 5.52±0.99),TC (183.85±55.68 to 145.20±31.36mg/dL), TG (152.50±37.59 to 130.40±27.96mg/dL), LDL-C (127.35±23.45 to 111.40±25.71mg/dL), and MDA (1.65±0.15 to 1.49±0.15nmol/mL).However, the serum TAC significantly increased (1.93±0.12 to 1.97±0.09mmol/L) (P<0.05).Anthropometric measurements did not differ remarkably between groups.Post-dose significant inter-group differences in FBS, serum insulin, HOMA-IR, TC, TG, LDL-C, MDA, and TAC levels were identified after adjusting for baseline values (P<0.05).This study demonstrated that coriander seed supplementation positively improved glycemic indices, lipid profile, and oxidative stress status in patients with T2DM, suggesting its potential as a useful complementary treatment for managing this condition.

Source: Preventive Nutrition and Food Science

DOI: 10.3746/pnf.2025.30.6.529

Authors: Sanaz Zamany, Ali Barzegar, Baharak Aghapour, Faranak Ferdosi

Institution: Tabriz University of Medical Sciences

Language: English

Topic: Natural Antidiabetic Agents Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Tabriz University of Medical Sciences, University of Tabriz