Racial and Ethnic Diversity in Clinical Trials for Disease Modifying Drugs in Parkinson Disease: A Systematic Review & Meta‐Analysis
Year: 2025
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND: There is a historic underrepresentation of non-White participants in Parkinson's Disease (PD) research, although this has not been explored in trials for potential disease-modifying therapies. OBJECTIVE: To evaluate the representation of racial/ethnic minority patients enrolled in double-blind, randomized, placebo-controlled clinical trials (DBRCTs) for PD. METHODS: A systematic search of four electronic databases was performed. DBRCTs evaluating pharmacological therapies for disease modification in PD were included. Data extraction followed PRISMA guidelines. We computed demographic data with pooled prevalence and 95% confidence intervals (CIs). RESULTS: Among 37 DBRCTs and 11,022 patients, 19 studies (51.4%) reported race/ethnicity, being 1.4% Asian, 0.19% Black, and 0.17% Hispanic. Pooled prevalence of participants identified as White in clinical trials was 98% (CI 0.97-0.99, P < 0.001). CONCLUSION: Racial and ethnic minorities were disproportionately underrepresented in DBRCTs for potential disease-modifying therapies for PD. Additional efforts are required to increase the racial and ethnic representation in such studies.
DOI: 10.1002/mdc3.70482
Institutions: Universidade Federal de Viçosa, Universidade Federal de Ciências da Saúde de Porto Alegre, Universidade Estadual de Campinas (UNICAMP), Andhra University, Universidade Federal de Santa Catarina, Mater Misericordiae University Hospital, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, University of Colorado Anschutz, Washington University in St. Louis
Language: English
Topic: Ethics in Clinical Research
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Institute on Aging
OpenAlex ID: W7117549088