Diagnostic Performance of a Novel AI–Guided Coronary Computed Tomography Algorithm for Predicting Myocardial Ischemia (AI-QCTISCHEMIA) Across Sex and Age Subgroups
Year: 2025
Type: article
Abstract: Background: for predicting myocardial ischemia across these subgroups. Methods: This post-hoc analysis included symptomatic patients with suspected coronary artery disease from the CREDENCE (Computed Tomographic Evaluation of Atherosclerotic Determinants of Myocardial Ischemia) (n = 305; 868 vessels) and PACIFIC-1 (Comparison of Coronary Computed Tomography Angiography, Single Photon Emission Computed Tomography [SPECT], Positron Emission Tomography [PET], and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve) (n = 208; 612 vessels) studies. All patients underwent coronary computed tomography angiography, myocardial perfusion imaging (SPECT and/or PET), and invasive coronary angiography with 3-vessel fractional flow reserve as the reference standard. Diagnostic performance was evaluated at the vessel level using receiver operating characteristic analysis and under the curve (AUC), stratified by sex and age groups. Results: = .338). Conclusions: demonstrated consistently high diagnostic performance to detect myocardial ischemia across sex and age groups, significantly outperforming SPECT and showing comparable performance with PET, supporting its role as a noninvasive alternative for ischemia assessment.
Authors: Putri Annisa Kamila, Tara Hojjati, Nick S. Nurmohamed, Ibrahim Danad, Yipu Ding, Ruurt A. Jukema, Pieter G. Raijmakers, Roel S. Driessen, Michiel J. Bom, Pepijn van Diemen, Gianluca Pontone, Daniele Andreini, Hyuk-Jae Chang, Richard J. Katz, Andrew D. Choi, Paul Knaapen, Jeroen J. Bax, Alexander van Rosendael, Ran Heo, Hyung-Bok Park, Hugo Marques, Wijnand J. Stuijfzand, Jung Hyun Choi, Joon-Hyung Doh, Ae-Young Her, Bon-Kwon Koo, Chang-Wook Nam, Sang-Hoon Shin, Jason Cole, Alessia Gimelli, Muhammad Akram Khan, Bin Lu, Yang Gao, Faisal Nabi, Mouaz H. Al-Mallah, Ryo Nakazato, U. Joseph Schoepf, Randall C. Thompson, James J. Jang, Michael Ridner, Chris Rowan, Erick Avelar, Philippe Généreux, Guus A. de Waard
Institutions: University of Brawijaya, Leiden University Medical Center, Arizona State University, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, University of Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam, Radboud University Medical Center, Nankai University, University of Milan, Centro Cardiologico Monzino, IRCCS Ospedale Galeazzi - Sant'Ambrogio, Yonsei University, Severance Hospital, Yonsei University Health System, George Washington University, University of Turku, Turku University Hospital
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,400
OpenAlex ID: W7117550841