Work

Duration of antibiotic therapy: with or without biomarkers?

Year: 2026

Type: article

Abstract: Antimicrobial resistance has emerged as a critical global health challenge. Significant variability in antibiotic prescribing practices underscores the urgent need for high-quality evidence to inform optimal antibiotic prescribing policies. The ideal duration of antimicrobial therapy remains uncertain, and a one-size-fits-all approach is far from ideal. In this review, we examine bacterial growth kinetics and antibiotic pharmacodynamics and explore various strategies for determining the duration of antibiotic therapy: fixed duration, biomarker-guided, clinical course-based, and the more recent double-trigger approach.

Source: Acute and Critical Care

DOI: 10.4266/acc.002525

Authors: Gonçalo Sequeira Guerreiro, João Fustiga, Pedro Póvoa

Institutions: Hospital of St. Francis Xavier, University of Lisbon, Odense University Hospital, D’Or Institute for Research and Education, Comprehensive Health Research Centre, Universidade Nova de Lisboa

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7117554472

FWCI:

Cites: 29

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