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Targeted degradation of Pin1 by an antagonistic peptide enhances gemcitabine therapy in pancreatic cancer

Year: 2025

Type: article

Abstract: results demonstrated that both PIPWF and its nanoformulation M-PIPWF synergized with gemcitabine to induce tumor regression and prolong survival, illustrating a novel peptide-based TPD strategy against Pin1-driven malignancies.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00970g

Authors: Mengting Chen, Xiangyu Chu, Haipeng Zhao, Lilusi Ma, Jie Meng, Yanlian Yang, Qiaojun Fang, Xiaocui Fang, Chen Wang

Institutions: National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital

Language: English

Topic: Signaling Pathways in Disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Beijing Municipal Natural Science Foundation, National Key Research and Development Program of China

Awards: G2053624118, G3346909030, G8477732075

OpenAlex ID: W7117579196

FWCI:

Cites: 38

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