Concurrent Lepromatous Leprosy and Active Tuberculosis in A Young Male: A Complex Diagnostic and Therapeutic Challenge with Hematologic Manifestations
Year: 2025
Type: article
Study design: Case Report
Abstract: This report details the clinical evolution of a 23-year-old male presenting with the exceptionally rare co-occurrence of active lepromatous lerosy and tuberculous lymphadenitis, complicated by severe immune thrombocytopenia. The patient’s presentation—spanning chronic dermatological findings, acute systemic symptoms, and profound hematological disturbance—required a multifaceted diagnostic approach culminating in histopathological and microbiological confirmation of both mycobacterial infections. Management was successfully integrated, utilizing a single rifampin-based antitubercular regimen to simultaneously address both diseases, resulting in resolution of thrombocytopenia and significant clinical improvement. This case highlights the diagnostic complexity in co-endemic regions, the potential for tuberculosis to drive significant parainfectious hematologic complications, and the feasibility of a unified pharmacological strategy for dual mycobacterial disease.
Authors: Juan Fausto Martínez González, Ana Laura Ricarte González, Alma Elizabeth Díaz Gamiño, Leonel Castro López, Francisco Adrián Razo Moreno, Ana Victoria Pérez García, Mireya Nolasco Sanchez, Cristina Montserrat García Montalvo, Katia Gabriela Silva Esquivel, Mayra Aréchiga López, Alejandro Calderón Romo, Jonathan Guzmán Rodríguez, Ilse Nájera Basurto, Sergio Ronaldo Esparza Herrera, María José Soto Martínez, Karla Teresa Granados Velasco, Alexa Ximena Márquez Durón
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7117581798
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