Work

From bolinaquinone, a marine hydroxyquinone sesquiterpene, to naphthoquinones with clathrin inhibitory effects

Year: 2025

Type: article

Abstract: Bolinaquinone (1) is cited as a clathrin inhibitor; applying a DFT approach, naphthoquinones with similar electronic properties were designed and shown to be potent inhibitors of the clathrin N-terminal domain–amphiphysin interaction, e.g. 23.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d5md00900f

Authors: Nicholas S. O'Brien, Azadeh Ghods, Jing Xue, Mary J. Garson, Ken W. L. Yong, Jennette A. Sakoff, Jayne Glibert, Megan Chircop, Uwe Fink, Volker Haucke, Phillip J. Robinson, Adam McCluskey

Institutions: University of Newcastle Australia, The University of Sydney, Children's Medical Research Institute, The University of Queensland, Calvary Mater Newcastle Hospital, Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Language: English

Topic: Bioactive Compounds and Antitumor Agents

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funder: Australian Research Council

Award: G2750193811

OpenAlex ID: W7117583673

FWCI: 1.353

Cites: 76

Cited by: 1

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