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Complete Response with Modified FLOX in Metastatic Colon Cancer: A Case Report

Year: 2025

Type: article

Abstract: Colorectal cancer (CRC) is one of the main causes of death by cancer. Patients diagnosed with colon adenocarcinoma and unresectable liver metastases have a poor prognosis, with a median overall survival (OS) of 24 months. We herein report the case of a 7-year sustained complete response (CR) with 2 cycles of modified 5-fluorouracil plus oxaliplatin (mFLOX) in a metastatic setting. The patient is a White Brazilian male aged 59 years. There is scarce evidence on the clinical evolution of non-operable patients with metastasis to establish a definitive cure only with a chemotherapy regimen, without complimentary liver resection. The patient herein reported achieved CR with only two cycles of treatment, which is not usual in this scenario. He was deemed non-operable because of the number and position of the lesions detected before the start of chemotherapy.

Source: Journal of Coloproctology

DOI: 10.1055/s-0045-1801891

Authors: Denis Artico Galhera, Camila Motta Venchiarutti Moniz

Institutions: Universidade de São Paulo, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7117585127