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Management of Vincristine Extravasation Using Dimethyl Sulfoxide

Year: 2025

Type: article

Abstract: Extravasation is a chemotherapy complication that limits optimum patient management and requires immediate attention. Hyaluronidase is the standard antidote suggested for use in vinca alkaloid-related extravasation injury as soon as possible. Here, we report a case of extensive cutaneous damage to the volar surface of the arm after receiving a vincristine infusion. Due to hyaluronidase not being available in our country, we used a dispersion of 10% Vitamin E in 99% dimethyl sulfoxide (DMSO), starting 8 days after the accident, which resulted in significant improvement. The lesion had completely improved in the last visit, with only post-inflammatory hyperpigmentation remaining. Due to the radical scavenging properties of DMSO, the use of said dispersion for vincristine extravasation injuries may be a potential option.

Source: Indian Journal of Paediatric Dermatology

DOI: 10.4103/ijpd.ijpd_122_24

Authors: Zahra Alimohammad Ghelichkhan, Mehran Norouzi, Sarah Mohsenzadeh

Institutions: Urmia University, Urmia University of Medical Sciences

Language: English

Topic: Chemotherapy-related skin toxicity

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7117587692

FWCI:

Cites: 8

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