Figure 3 from Phase 1b Study of Dazostinag plus Pembrolizumab after Hypofractionated Radiotherapy in Patients with Select Advanced Solid Tumors
Year: 2025
Type: other
Abstract: scRNA-seq data from a single patient with tumor biopsy prior to and after dazostinag and pembrolizumab administration following RT. A, UMAP of lymphocytes colored by cell type (left) and sampling time (right). B, Cell type ratio to total lymphocytes in screen and C1D15 samples, with NK and NKT-like cells highlighted in dashed box. C, Hallmark GSEA of upregulated genes in lymphocytes comparing C1D15 with screen samples. D, UMAP of myeloid cells colored based on sampling time (left), and Hallmark GSEA of upregulated genes in myeloid cells comparing C1D15 with screen samples (right). CD, cluster of differentiation; KRAS, Kirsten rat sarcoma virus; mTORC1, mTOR complex 1; NA, not applicable; STAT, signal transducer and activator of transcription; Treg, regulatory T cell.
Authors: Benjamin T. Cooper, Wade T. Iams, David B. Page, Yuan Yuan, Naamit K. Gerber, Jason J. Luke, John P. Gibbs, Richard C. Gregory, Kwok-Kin Wong, Jiehui Deng, Samanthi A. Perera, Kai Ding, Emily R. Roberts, Allison Berger, Camilla L. Christensen, Erica Xin Tong, Angel E. Maldonado López, Vicky A. Appleman, E. Jane Leonard, Alexander Parent, Yu-Chung Huang, Camden Bay, Cong Li, Neil Lineberry, Jeffrey Raizer, Daniel J. Olson, Steven J. Chmura
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7117653096