Work

Discovery of DN1679 as a Potent, Orally Bioavailable, and Highly Selective CDK12/13 Dual Degrader for the Treatment of Triple-Negative Breast Cancer

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c02232

Authors: Danni Chen, Jiawen Hu, Yiling Yu, Kailin Li, Tingting Wang, Zidong Wang, Yi Yuan, Xuejing Shao, Meidan Ying, Bo Yang, Qiaojun He, Ji Cao, Li Jiang, Cheng-Liang Zhu

Institutions: Zhejiang University, Hangzhou City University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities

Awards: G119396533, G3397419030, G6141109040, G6886552159, G7375157031, G8008926582

OpenAlex ID: W7117673123

FWCI: 0.522

Cites: 24

Cited by: 2

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