Work

Concordance Analysis Between Sputum and Bronchoscopic Specimens on Nontuberculous Mycobacteria Pulmonary Disease

Year: 2025

Type: article

Abstract: Background/Objectives: This study evaluated the concordance between sputum and bronchoscopic specimens in diagnosing nontuberculous mycobacteria (NTM) pulmonary disease. Methods: We retrospectively analyzed patients with NTM isolated from respiratory specimens between 2010 and 2022. Our analysis assessed species concordance across the two diagnostic methods and compared clinical outcomes between patients with multiple positive cultures and those with a single positive culture. Results: A total of 400 patients were included, 100 of whom underwent bronchoscopy. Among these, 61 demonstrated concordant NTM species between sputum and bronchoscopic specimens, while 38 had NTM cultured from only one source. One patient showed a discordant result, with Mycobacterium abscessus isolated from bronchoalveolar lavage and Mycobacterium avium from sputum. Multivariate analysis identified several factors associated with radiologic progression or the need for treatment: body mass index (HR, 0.847; 95% CI, 0.794–0.902; p < 0.001), membership in the single-isolation group (HR, 0.400; 95% CI, 0.184–0.871; p = 0.021), and fibrocavitary radiologic type (HR, 2.318; 95% CI, 1.470–3.655; p < 0.001). Conclusions: Only a small number of cases showed different NTM species identified by sputum and bronchoscopy.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm15010296

Authors: Sojung Park, Jin Hwa Lee, Nam Eun Kim, Yune-Young Shin

Institutions: Ewha Womans University, Ewha Womans University Seoul Hospital

Language: English

Topic: Mycobacterium research and diagnosis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137