Advanced Catalysts for Olefin Synthesis: Copper(II) Quinoline-Fused Oxazolidines in Alcohol Dehydration
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide The new copper(II) catalyst [Cu( Q FOX)(CH 3 CN)][OTf] 2 has been synthesized and found to be active for alcohol dehydration to give olefins at 120 °C with a 1% catalyst loading ( Q FOX = di-2-quinolinyl-fused-oxazolidine). Benzylic, allylic, and tertiary alcohols are all dehydrated. In some cases, ethers are observed to be produced, but these are re-entrained into the catalytic cycle. Unactivated secondary alcohols are also dehydrated. Similar catalysts employing Mn II, Fe II, Co II, and Ni II were also synthesized but showed reduced dehydration activity compared to the copper(II) derivative. A Cu I analog was also prepared but did not show improved dehydration activity.
Source: The Journal of Organic Chemistry
Institution: University of Rochester
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W7117686153