Work

Evaluation of hydroalcoholic extract of Licorice (Glycyrrhiza glabra L.) root on treatment of experimentally induced peritonitis in New Zealand male rabbits

Year: 2025

Type: article

Abstract: This experimental study evaluated the therapeutic potential ofaliquorice-derived hydroalcoholic extract inmanaging experimentally induced peritonitis inNew Zealand rabbits. The animals were randomly divided into six groups (n=6): one control group, one negative control group (infected but untreated), three treatment groups that received the liquorice-derived extract at0.5, 1, and 2g/kg, and one positive control group treated with enrofloxacin. The confirmation ofperitoneal infection relied onhistopathological and radiographic tests. The effect ofthe liquorice extract onthe peritoneal infection was evaluated using biochemical, haematological, and ultrasound analyses across the groups. The ultrasound examination, along with the haematological and biochemical evaluation onthe 20thday after induction, showed significant differences between the groups. The results demonstrated that higher doses of 1 g/kg and 2 g/kg were more effective than the lower dose of 0.5 g/kg. The haematological and biochemical analyses revealed significant differences in several variables (including WBC, neutrophils, fibrinogen, and liver enzymes) between the treated and control groups, with the most pronounced improvements observed in the group receiving 2 g/kg of liquorice extract, suggesting a dose-dependent therapeutic effect. The administration of a hydroalcoholic extract of liquorice at different doses, along with the standard treatment with enrofloxacin, affected various haematological and biochemical variables in the context of peritoneal infection management. In conclusion, the effectiveness of the liquorice-derived extract is dose-dependent and could be used as an effective therapeutic agent in peritoneal infections in New Zealand rabbits. These findings showed that the liquorice-derived extract effectively improves the local inflammatory and structural changes associated with peritoneal infection without adversely affecting systemic biochemical homeostasis.

Source: Veterinární Medicína

DOI: 10.17221/31/2025-vetmed

Authors: M Ahmadi, I Nowrouzian, M Norbakhsh, M Yadegari, M Jafarian Dehkordi

Institutions: Islamic Azad University of Shahrekord, University of Tehran

Language: English

Topic: Pharmacological Effects of Natural Compounds

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $609