Work

Triglyceride-glucose body mass index and the risk of gestational diabetes mellitus: a population-based cohort study

Year: 2025

Type: article

Abstract: Background: The purpose of this analysis was to investigate the association between triglyceride-glucose body mass index (TyG-BMI) and gestational diabetes mellitus (GDM) in Chinese pregnant women. Methods: This observational study utilized a cohort of pregnant women who were screened for GDM using the oral glucose tolerance test (OGTT). The TyG-BMI was calculated using the formula: TyG index = ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2). TyG-BMI = TyG × BMI. Statistical analyses were performed to assess the correlation between TyG-BMI and gestational diabetes mellitus incidence. Results: < 0.05). Compared to the lowest quartile of TyG-BMI, the third quartile of TyG-BMI is associated with the highest risk of developing gestational diabetes mellitus (OR: 1.8; 95%CI: 1.28 ~ 2.52). All models showed similar results. The stratified analyses were performed to examine whether the association between TyG-BMI and GDM was stable among different subgroups. None of the variables, including age (< 35 years and ≥35 years), premature delivery (yes or no), and vaginal birth (yes or no), significantly affected the association between TyG-BMI and GDM (all P for interaction > 0.05). Conclusion: A cohort study of Chinese pregnant women concluded that TyG-BMI might be a valuable index for identifying IR in patients at high risk of gestational diabetes mellitus. TyG-BMI could be recommended as part of routine surveillance during early pregnancy.

Source: Frontiers in Nutrition

DOI: 10.3389/fnut.2025.1657186