Work

A Review of ARID1A’s Role in Breast Cancer Progression: Context-Dependent Mechanisms and Therapeutic Implications

Year: 2025

Type: article

Abstract: ARID1A, a key subunit of the SWI/SNF chromatin remodeling complex, plays a context-dependent function in cancer, acting both as a tumor suppressor and, in certain conditions, as an oncogene. ARID1A, as a tumor suppressor, maintains transcriptional regulation, genomic stability, and cellular differentiation. In breast cancer, ARID1A loss-of-function leads to dysregulation of cell cycle checkpoints and impaired DNA repair and promotes epithelial-to-mesenchymal transition (EMT), jointly accelerating tumor proliferation and increasing therapeutic resistance. Notably, context-dependent ARID1A loss-of-function often concurs with activation of the PI3K/AKT signaling pathway and corresponds with poor prognosis. On the contrary, aberrant ARID1A overexpression can provoke oxidative stress and agitate the cytochrome P450 system, potentially facilitating early tumorigenesis. Consequently, understanding ARID1A's dual and context-dependent role highlights its potential as a biomarker and therapeutic target in precision oncology.

Source: Cancers

DOI: 10.3390/cancers18010142

Authors: Gopalakrishnan Shankari, Dhamodharan Prabhu, Muthusamy Sureshan, Jeyaraman Jeyakanthan, Sundararaj Rajamanikandan

Institutions: Karpagam Academy of Higher Education, Alagappa University, Tianjin University

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499