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Neutrophil‐Mediated Mechanisms and Therapeutic Reversibility of Gastric Intestinal Metaplasia

Year: 2025

Type: article

Abstract: Gastric intestinal metaplasia (GIM), a precancerous gastric lesion, represents a critical transitional stage in the Correa cascade that progresses from chronic inflammation to gastric adenocarcinoma (GAC). Emerging evidence implicates neutrophils as key orchestrators of GIM pathogenesis through multifaceted interactions within the tumor microenvironment. Therapeutic strategies targeting neutrophil activation, migration, and effector functions, including autophagy modulation and phenotypic reprogramming to an anti-inflammatory N2 state, hold promise in reversing GIM progression. This review synthesizes the current knowledge on neutrophil-mediated mechanisms and explores clinically actionable pathways for GIM reversibility.

Source: Journal of Gastroenterology and Hepatology

DOI: 10.1111/jgh.70214

Authors: Yu Huang, Siqing Xie, Chunyan Yan, Junyong Zhang

Institutions: Shandong University of Traditional Chinese Medicine, Shandong Provincial Hospital, Shandong First Medical University

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7117722720

FWCI: 0.298

Cites: 165

Cited by: 1

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