Work

Fe-BPsalan Complex-Catalyzed Asymmetric 1,3-Dipolar [3 + 2] Cycloaddition of Nitrones with α,β-Unsaturated Acyl Imidazoles

Year: 2025

Type: article

Abstract: A highly efficient, iron(III)-BPsalan complex-catalyzed asymmetric 1,3-dipolar cycloaddition of nitrones and α,β-unsaturated acyl imidazoles has been developed to afford isoxazolidine (31 examples) and isoxazoline derivatives (13 examples) in moderate to excellent yields (up to 99%) and excellent stereoselectivity (up to 99% ee and >20:1 dr). The reaction proceeds readily in acetone under air conditions, maintaining high efficiency and selectivity.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c02152

Authors: Gong-Xin Li, Zhen-Jiang Xu, Chi-Ming Che

Institutions: National Medical Products Administration, Shanghai Institute of Organic Chemistry, Henan Normal University, State Key Laboratory of Synthetic Chemistry, University of Hong Kong

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Research Grants Council, University Grants Committee, Innovation and Technology Commission, CAS-Croucher Funding Scheme for Joint Laboratories