Work

Melkersson‑Rosenthal syndrome with facial swelling and palsy and associated diagnostic challenges: A case report

Year: 2025

Type: article

Abstract: Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder characterized by recurrent orofacial edema, peripheral facial palsy and a fissured tongue, although the complete triad is rarely observed. The present study reports the case of a 22-year-old male patient who initially presented with facial paralysis, later developing cheek edema, dermatosis and systemic symptoms; the histopathological findings consistent with granulomatous cheilitis. Laboratory analyses revealed a low C1q level and positive antinuclear antibody. Based on clinical and biopsy findings, MRS was diagnosed. The patient responded well to a 6-month regimen of deflazacort, epinastine and methotrexate. On the whole, the present case report illustrates an incomplete, yet clinically significant form of MRS. Diagnosis is primarily clinical, supported by histology and exclusion of similar conditions. Treatment focuses on symptom control with corticosteroids; immunomodulators or biologics may be used in refractory cases. Early recognition is essential, even in the absence of the full triad.

Source: Medicine International

DOI: 10.3892/mi.2025.294

Authors: Alina Sánchez Vázquez, Anahí Parcero Tamay, María Calvo Domínguez, Martha Pacheco Arenas, Valeria Medrano Pichardo

Institution: Institute for Social Security and Services for State Workers

Language: English

Topic: Autoimmune and Inflammatory Disorders

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado