Work

ApCAFs: spatial niches and therapeutic insights across cancers

Year: 2025

Type: article

Abstract: Although interest in antigen-presenting cancer-associated fibroblasts (apCAFs) is increasing, their therapeutic potential remains poorly understood. In a recent study, Chen et al. reveal two osteopontin-expressing apCAF populations present across malignancies and distinct in origin and location: mesothelial-like (M-)apCAFs, which are found near cancer cells, and fibrocyte-like (F-)apCAFs, which associate with lymphocyte-enriched niches.

Source: Trends in cancer

DOI: 10.1016/j.trecan.2025.12.005

Authors: Wenlong Li, Gideon Nsubuga, Giulia Biffi

Institutions: University of Cambridge, Cancer Research UK, Cancer Research UK Cambridge Center

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030