Work

Silk Fibroin With Enhanced Hemostatic Property by the Introduction of Carboxyl Moieties and Preservation of Micrometer Scale Fiber Architecture

Year: 2025

Type: article

Abstract: In the realm of clinical surgery, the unceasing pursuit of hemostatic materials with rapid hemostasis, excellent biocompatibility, degradability, wound-healing promotion, and economic viability is of utmost importance. This study, inspired by the preparation and hemostatic mechanism of Surgicel®, a prevalent surgical hemostatic agent, low-cost silk fibroin (SF) was modified. By adding carboxyl groups while maintaining the SF micron-fiber structure, the modified SF showed enhanced water and blood absorption, as well as a significantly improved Ca²⁺ transport capacity compared to unmodified SF. In vitro coagulation tests revealed that the modified SF had excellent hemostatic efficacy, with the quickest time at 76.75 ± 2.17 s. In the animal bleeding model, its fastest hemostatic time was 93 ± 9.63 s, with a mean blood loss of 0.28 ± 0.05 g, similar to Surgicel® (100.64 ± 2.87 s, 0.24 ± 0.05 g). Moreover, the modified SF hemostatic yarns exhibited favorable blood, cell, and biocompatibility, making them a promising option for surgical wound hemostasis, especially in organ surgery.

Source: Biotechnology and Bioengineering

DOI: 10.1002/bit.70148

Authors: Mingyu Jiang, Fuping Wang, Jun Zhang, Changfu Hu, Guobao Chen, Zhongmin Chen

Institutions: Chongqing University of Technology, Chongqing Three Gorges Medical College

Language: English

Topic: Silk-based biomaterials and applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Chongqing University, Chongqing University of Technology, Natural Science Foundation of Chongqing, Division of Graduate Education