Work

A Randomized, Double-Blind, Contralateral Eye Study Comparing the Clinical Outcomes of Two Types of Silicone Hydrogel Bandage Contact Lenses After Transepithelial Photorefractive Keratectomy

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background: To compare clinical outcomes of Lotrafilcon A and Balafilcon A silicone hydrogel bandage contact lenses (BCLs) following transepithelial photorefractive keratectomy (TPRK). Methods: A randomized, double-blind, contralateral eye study enrolled 41 TPRK patients (82 eyes), with each eye randomly assigned one BCL type. Assessments included uncorrected (UDVA) and corrected (CDVA) distance visual acuity, ocular pain and irritation, epithelial healing, limbal and conjunctival hyperemia, lens mobility, and the amount of protein deposition on the BCLs. Results: Postoperative day 1 pain score was lower in Group A (2.80 ± 2.35) than in Group B (4.44 ± 2.46, p = 0.003). Group A had significantly less protein deposition (day 3: 9.92 ± 9.82 vs. 25.75 ± 9.86 μg, p < 0.001; day 4: 9.47 ± 10.06 vs. 32.60 ± 16.71 μg, p = 0.005). No statistically significant differences were observed between the two groups in terms of corneal epithelial defect area, corneal epithelial healing time, UDVA, CDVA, limbal or conjunctival hyperemia, and lens movement. Conclusions: Lotrafilcon A outperformed Balafilcon A in reducing ocular pain, foreign body sensation, and protein deposition, suggesting that Lotrafilcon A may be a more suitable therapeutic BCL option following TPRK.

Source: Bioengineering

DOI: 10.3390/bioengineering13010039

Authors: Ling Wang, Jiajia Jin, Lu Yan, Kaiyan Huang, Shihao Chen

Institutions: Wenzhou Medical University, Affiliated Eye Hospital of Wenzhou Medical College

Language: English

Topic: Ocular Surface and Contact Lens

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258