Work

Multivariate and multi-trait analyses in psychiatric genetics

Year: 2025

Type: article

Abstract: Psychiatric disorders exhibit complex genetic characteristics such as substantial polygenicity, pleiotropy, and genetic overlap, making them difficult to fully understand through studies focused solely on single genes or individual diseases. This review underscores the importance of multivariate and multi-trait analyses in psychiatric genetics and provides a comprehensive overview of major analytical tools, including their concepts, strengths, limitations, and applications. By addressing the current methodological challenges and proposing future directions, we aim to advance our understanding of the genetic architecture underlying psychiatric disorders and support progress towards precision medicine.

Source: Precision and Future Medicine

DOI: 10.23838/pfm.2025.00310

Authors: Shin-Won Lim, Hyun Seok Do, Soyeon Kim, Woojae Myung

Institutions: Kyung Hee University, Seoul National University, Seoul National University Bundang Hospital

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Naver Corporation, National Research Foundation, National Research Foundation of Korea, Ministry of Science and ICT, South Korea