Work

Tertiary lymphoid structures: Defining immune subtypes and enabling precision immunotherapy in nasopharyngeal carcinoma

Year: 2025

Type: article

Abstract: 1.1Definition and architecture of tertiary lymphoid structures Tertiary lymphoid structures (TLSs)-also referred to as ectopic lymphoid tissues or tertiary lymphoid organs 1 -are inducible lymphoid aggregates that arise in non-lymphoid tissues under chronic inflammatory conditions, such as cancer or autoimmune disease. 2 Mature TLSs share key architectural features with secondary lymphoid organs (SLOs), including B-cell follicles, T-cell zones, and high endothelial venules (HEVs).A defining distinction, however, is their lack of a fibrous capsule, which alters patterns of lymphocyte trafficking and shapes the initiation of local immune responses within the tumour microenvironment (TME).3 Inductive mechanisms of TLS formationTLS formation is a multistep process driven by sustained inflammatory stimuli.Chronic infection, autoimmunity, or tumour-induced inflammation provides the

Source: Clinical and Translational Discovery

DOI: 10.1002/ctd2.70111

Authors: Fan Liu, Lei Xiong, Xia Yu, Mingfang Ji

Institutions: Guangdong Medical College, Zhongshan People's Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,420