Get started
Work

Dynamic monitoring of left atrial strain: a novel paradigm for early detection of cardiotoxicity in colorectal cancer patients undergoing chemotherapy

Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Chemotherapy-induced cardiotoxicity significantly impacts cancer prognosis, yet conventional assessment methods lack sufficient sensitivity for early detection. This study aimed to evaluate the dynamic changes of left atrial (LA) strain parameters and their utility as diastolic function markers in colorectal cancer patients receiving chemotherapy. Methods: In this prospective cohort study, 94 patients treated with FOLFOX/XELOX regimens underwent comprehensive echocardiographic assessments at baseline (T0), after the first cycle (T1), mid-therapy (T2), and treatment completion (T3). Left atrial reservoir (LASr), conduit (LAScd), and contractile (LASct) strains, and left ventricular global longitudinal strain (LVGLS) were analyzed using speckle-tracking echocardiography. Linear mixed models characterized strain parameter trajectories, while latent class growth analysis identified heterogeneous response patterns. Correlation matrices evaluated associations between LA strain, LVGLS, and diastolic parameters, with receiver operating characteristic (ROC) curve analysis determining diagnostic performance. Results: 16.4%, P=0.007) and greater LASct impairment (2.1% reduction, P=0.012). Conclusions: LA strain parameters, particularly LASr, serve as sensitive biomarkers for chemotherapy-associated diastolic dysfunction, demonstrating diagnostic superiority over conventional measures. The observed strain progression patterns enable individualized risk stratification, providing a rationale for early cardioprotective interventions.
DOI: 10.21037/qims-2025-1909
Authors: Zhen Wang, Kundi Chen, Ting Wang, Yuqiong An, Chuanmin Wei, Ran Zheng, Fang Nie
Language: English
Field: Medicine
Open Access status: diamond
OpenAlex ID: W7117787309
FWCI:
Cites:
Cited by:
Related to: