Work

Pox-AbDab: the orthopoxvirus antibody database

Year: 2026

Type: article

Abstract: In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential therapeutic interventions. Here, we presented the Orthopoxvirus Antibody Database (Pox-AbDab), a repository of data on antibodies known to bind or neutralise viruses from the same genus as mpox (https://opig.stats.ox.ac.uk/webapps/poxabdab). Beyond standardising and centralising the data, we highlighted challenges in translating knowledge across orthopoxviruses, such as the absence of a function-based nomenclature for virion surface antigens. We also performed an exploratory analysis of the known orthopoxvirus-binding antibody landscape, highlighting their aggregate molecular properties, cross-binding/cross-neutralisation profiles, evidence for immunodominance or immune escape from their epitopes, and gaps in coverage to help orient future research. Systematic review: Code available at: https://opig.stats.ox.ac.uk/webapps/poxabdab.

Source: Frontiers in Immunology

Authors: Henriette L. Capel, Eric Ji Da Wang, Benjamin H. Williams, Charlotte M. Deane, Matthew I. J. Raybould

Institution: University of Oxford

Language: English

Topic: Poxvirus research and outbreaks

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801

Funders: Coalition for Epidemic Preparedness Innovations, Engineering and Physical Sciences Research Council