Work

A Modern Approach to Combating HPV: Integrating Molecular Diagnostics, Population-Based Prevention, and Vaccination Strategies

Year: 2025

Type: article

Abstract: Human papillomavirus (HPV) can cause asymptomatic infections, making it part of the human microbiota. Some HPV types cause benign proliferative lesions, such as warts or condylomas, while highly oncogenic types, in the context of chronic infection, can induce lesions that may progress to cancer. The article presents current knowledge on HPV biology, carcinogenesis, and risk factors modulated by co-infections with other viruses or bacteria. The paper also reviews contemporary diagnostic strategies, ranging from cytology (conventional and LBC) and DNA/mRNA (E6/E7) tests to highly sensitive NAAT and sequencing methods. Prevention through available vaccination programs is discussed. From a public health perspective, the importance of adolescent vaccination programs and screening tests, which effectively reduce the incidence of infection and mortality associated with HPV-related cancer, is emphasized.

Source: Postępy Mikrobiologii - Advancements of Microbiology

DOI: 10.2478/am-2025-0022

Authors: Katarzyna Biegun-Drożdż, Sława Szostek, Monika Brzychczy-Włoch

Institution: Jagiellonian University

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $123