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Ten Key Questions on the 2023 Bethesda “AUS” Category: Practical Guidance for Surgeons, Endocrinologists, and Pathologists

Year: 2025

Type: article

Abstract: The 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) redefines Atypia of Undetermined Significance (AUS) by introducing subclassification into AUS with nuclear atypia and AUS-other. This change reflects growing evidence that the risk of malignancy is subtype-dependent. For endocrine surgeons, this means that cytology can no longer be interpreted in isolation: AUS subtypes must be integrated with ultrasound patterns and, when appropriate, molecular data to guide individualized management.

Source: Revista Portuguesa de Cirurgia

DOI: 10.34635/rpc.1129

Authors: Canberk, Sule, Simplício, Mariana, Bongiovanni, Massimo, Rodrigues, Elisabete, Capela, João

Institutions: Universidade do Porto, Unilabs (Switzerland), Hospital de São João

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7117992861

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