TNA in Immune Systems: Throughput, Incoherence, and the Mechanics of Immunological Stability
Year: 2026
Type: article
Abstract: The immune system is traditionally modeled as a network of innate and adaptive responses regulated by pathogen recognition, cytokine signaling, and feedback loops. This paper proposes a TNA-based framework, viewing immunity as an open non-equilibrium system where immune coherence requires continuous throughput (Ψ) to discharge incoming incoherence (G). When G exceeds Ψ, accumulated incoherence (ℵ) manifests as chronic inflammation, autoimmunity, or impaired pathogen clearance. Phenomena such as chronic infections, autoimmune disease, and immunosenescence can be reframed as throughput saturation rather than primary cellular defects. The model is falsifiable, predictive, and integrates mechanistic, lifestyle, and clinical data, providing a unified framework for immune stability and failure.
Author: Bresciano, Claudio
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7118128305
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