Work

Evaluating the role of graft angle on cerebral hemodynamics following direct cerebral bypass for moyamoya disease

Year: 2026

Type: article

Abstract: Direct cerebral bypass is a key treatment for moyamoya disease (MMD). This surgery grafts a donor vessel onto a recipient cerebral artery to boost blood flow to hypoperfused brain regions. Unlike coronary bypass, which restores downstream flow around a blockage, cerebral bypass for MMD reverses flow in the recipient vessel to perfuse the upstream network. Surgical decisions-such as donor vessel choice and anastomosis angle-significantly affect graft hemodynamics and outcomes. Yet these choices still rely on neurosurgeons' experience, lacking quantitative guidance. This study addresses that gap by examining how anastomosis angle shapes post-surgical perfusion and wall shear stress. We created idealized cerebral bypass models with graft angles of 30°, 60°, and 90°. Each model's flow field was assessed under varying inflow and graft-flow combinations using computational fluid dynamics. The 30° angle produced the strongest reverse flow but also the largest WSS imbalance, potentially driving long-term complications. The 60° angle achieved adequate reverse flow with a more uniform WSS profile, making it the most favorable. Overall, our results show graft angle must be carefully considered in cerebral bypass planning.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0330362

Authors: Cheng Peng, Ephraim W. Church, Melissa C. Brindise

Institutions: Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: Moyamoya disease diagnosis and treatment

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382