Work

16-Week Trial of Pineal 10x on Hormonal Balance and Sleep

Year: 2026

Type: article

Abstract: This document presents a 16-week independent pilot study investigating the effects of the dietary supplement Pineal 10x on hormonal balance and sleep architecture. In an open-label trial with 28 healthy adult completers, supplementation was associated with a significant reduction in evening salivary cortisol and concurrent improvements in actigraphy-measured sleep efficiency and consolidation. No significant changes were observed in serum melatonin or other major endocrine axes. The findings suggest the supplement's effects may be mediated through adaptogenic modulation of stress physiology rather than direct pineal activation, highlighting the need for placebo-controlled research to confirm these preliminary results.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18144990

Author: Sharma, Anya

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7118186852

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