Work

Synthesis and crystal structure of HDAC6 selective inhibitor of N -hydroxy-4-{2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl}benzamide monohydrate (HPOB·H 2 O)

Year: 2026

Type: article

Abstract: The synthesis and crystal structure of the title compound N -hydroxy-4-{2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl}benzamide monohydrate ( HPOB · H 2 O ) is reported. The water molecule is positionally disordered at 106 K. The complex crystallizes with monoclinic P 2 1 / n symmetry, and the core of the molecule is relatively planar with the two aryl substituents rotated out of the plane. This structure highlights how HPOB · H 2 O has a hydroxamate moiety that adopts a Z conformation.

Source: Acta Crystallographica Section E Crystallographic Communications

DOI: 10.1107/s2056989025010989

Authors: Zola Cervantes, Lauren Bradford, Andressa Antonini Bertolazzo, Adaickapillai Mahendran, S. Chantal E. Stieber

Institution: California State Polytechnic University

Language: English

Topic: Crystal structures of chemical compounds

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $500

Funders: National Science Foundation, U.S. Department of Defense, U.S. Department of Education, California State Polytechnic University, Pomona