Year: 2026
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Background Osteoporosis significantly impacts global morbidity. Recent evidence suggests anaemia may contribute to osteoporosis risk. This systematic review and meta-analysis investigates this association.Methods PubMed, Scopus, EBSCO, and ScienceDirect were searched for papers. Studies with definition of anaemia and assessing osteoporosis outcomes were included. Meta-analysis utilized random-effects models (DerSimonian-Laird method), and study quality was assessed via Newcastle-Ottawa Scale (NOS). Analyses were performed using R Studio.Result Eighteen studies (861,540 participants) were analyzed. Anaemia significantly increased osteoporosis risk in univariate analysis (OR 1.62; 95% CI 1.33–1.98; p < 0.001), despite high heterogeneity (I2 = 92.7%). The results remain significant in studies that reported multivariate analysis (OR 2.01; 95% CI 1.26–3.21; p = 0.004). Sensitivity analyses confirmed the robustness of our result.Conclusion Anaemia significantly associated with osteoporosis, emphasizing the need for targeted screening in anaemic individuals. Further studies should consider incorporating anaemia into osteoporosis and fracture prediction tools.
Source: Annals of Medicine
Authors: Alveron Andreas Tear, Florencia Anastasia Tesno, Haneira Shofiadeita, Gading Marcell Bunga, Hamidah Nur Taqiya, Najwa Audrey Sanditha, Ayesha Humayra Fayyaza, Samantha Kerenhapukh Tiurlina Tambunan, Gisela Kayla Wangsa, Qanita Reezqi Fatimah, Istiqomah Istiqomah, Widya Wibawanty, Leonardo Lubis
Institution: Padjadjaran University
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,557
OpenAlex ID: W7118309048