Work

Emerging Therapeutic Strategies for Nrf2-Associated Skin Disorders: From Photoaging to Autoimmunity

Year: 2026

Type: article

Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of the cellular antioxidant response, modulating redox homeostasis, detoxification, and cytoprotective pathways. Impaired Nrf2 signaling has been associated with a wide range of cutaneous pathologies, including photoaging, autoimmune disorders, and inflammation. In this review, we highlight roles of Nrf2 in the physiological and pathological mechanisms underlying oxidative stress, autoimmunity-associated skin damage, and fibrotic diseases, with a particular emphasis on photoaging, psoriasis, vitiligo, and autoimmune-associated skin fibrosis. Furthermore, we elucidate several natural bioactive compounds, their therapeutic applications, and delivery platforms for mitigating oxidative stress-mediated skin damage through the modulation of Nrf2 signaling, aiming to translate basic insights into clinical interventions for oxidative stress-driven skin disorders.

Source: Antioxidants

DOI: 10.3390/antiox15010069

Authors: Hyeong Jae Kim, Jeong Hee Hong

Institution: Gachon University

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499