Work

Shikonin-loaded porous graphdiyne nanofilm on titanium surface for enhanced antibacterial activity and osseointegration

Year: 2026

Type: article

Abstract: Bacterial infection, peri-implant inflammation, and poor osseointegration are primary causes of failure in titanium (Ti)-based implants. Surface functionalization provides a simple and effective strategy to overcome these challenges. In this study, we developed a multifunctional coating based on porous graphdiyne (GDY) nanofilm loaded with shikonin (Skn). GDY was synthesized on Ti surfaces via a copper-catalyzed reaction to form a porous nanostructure. Following Skn loading, a composite layer of tannic acid (TA) and poly ( N -isopropylacrylamide) (pNIPAM) was applied, resulting in the Ti-GDY@Skn-TP system. Upon near-infrared (NIR) irradiation, the GDY coating induced localized photothermal effects sufficient to eradicate bacteria. Concurrently, the thermo-responsive release of Skn suppressed early inflammation and promoted osseointegration by regulating macrophage polarization and inflammatory cytokine secretion. In vivo studies confirmed that Ti-GDY@Skn-TP implants effectively eliminated bacterial infections, attenuated acute inflammation, and enhanced bone tissue regeneration and implant integration. This multifunctional approach offers a promising strategy for the surface modification of Ti-based biomedical implants. • Porous graphdiyne nanofilm formed on Ti via copper-catalyzed synthesis. • Shikonin-loaded GDY coating enables thermo-responsive drug release. • NIR-triggered photothermal effect achieves efficient antibacterial activity. • Shikonin modulates macrophage polarization to reduce inflammation. • Enhanced osseointegration and bone regeneration on modified Ti implants.

Source: Bioactive Materials

DOI: 10.1016/j.bioactmat.2025.12.055