Association of CRP/Troponin Ratio with Mortality in Pneumosepsis Patients Admitted from the Emergency Department
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: This study aimed to investigate the association between the C-reactive protein (CRP)/troponin ratio at Intensive Care Unit (ICU) admission and mortality in patients with pneumosepsis admitted from the emergency department (ED). Materials and Methods: This retrospective, single-center cohort study included 40 adult patients admitted to the ICU with pneumosepsis between September 2024 and September 2025. Demographics, comorbidities, admission laboratory data (including CRP, troponin, and other biomarkers), disease severity scores (APACHE II, SOFA), need for respiratory support, inotrope use, and ICU outcomes were collected from electronic medical records. Patients were stratified into survivor and non-survivor groups. Continuous variables were compared using the Mann–Whitney U test, and categorical variables with the chi-square or Fisher’s exact test. Results: ICU mortality occurred in 23 patients (57.5%), whereas 17 patients (42.5%) survived to hospital discharge. The CRP/troponin ratio was significantly lower in non-survivors (3.7 [IQR: 1.4–8.7]) compared to survivors (8.9 [IQR: 4.0–51.8], p = 0.006). Troponin levels were significantly higher in non-survivors (24.4 vs. 9.7 ng/L, p = 0.005). Non-survivors required longer invasive mechanical ventilation (p < 0.001) and had greater inotrope use (p = 0.004). APACHE II and SOFA scores were higher in non-survivors but did not reach statistical significance. Conclusion: A lower CRP/troponin ratio at ICU admission was strongly associated with mortality in ED-admitted pneumosepsis patients. This ratio may represent a simple and readily available prognostic tool that could improve early risk stratification and guide management strategies.
Institution: Sağlık Bilimleri Üniversitesi
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7118382147