Neonatal neurocritical care considerations for prenatally identified neurological disorders
Year: 2026
Type: article
Abstract: With increased access to advanced prenatal neuroimaging and genetic testing, neurological disorders such as brain malformations, brain injuries, and genetic disorders, are increasingly being diagnosed during pregnancy. In this review, we address neonatal neurocritical care considerations for the population with prenatally identified neurological disorders. We identify antenatal considerations, including planning location of delivery, as well as postnatal considerations, including clinical phenotyping, neuromonitoring, neuroimaging, and genetic testing. The importance of interdisciplinary collaboration between obstetrics, maternal-fetal medicine, neonatology, pediatric neurology, neuroradiology, genetics, palliative care, early intervention and habilitative services is emphasized. We outline high-priority research gaps, and highlight the need for large, multicenter studies that capture diverse geographies, populations, care practices and settings longitudinally. IMPACT: Fetal neurology is a rapidly evolving field owing to the increased prenatal diagnosis of neurological disorders; however, the natural history of many fetal neurological disorders is not well known. We identify interdisciplinary neonatal neurocritical care considerations for newborns with prenatally diagnosed neurological disorders, such as neuroimaging, neuromonitoring, and family support. We outline high-priority research gaps in fetal neurology relevant to neurocritical care, including the need to prioritize large-scale longitudinal studies on the etiologies, short- and long-term outcomes of fetal neurologic disorders across diverse geographies and populations to improve counseling and care.
Source: Pediatric Research
Authors: Dawn Gano, James P. Boardman, Sonika Agarwal, Charu Venkatesan, Tomo Tarui, Vann Chau, Courtney J. Wusthoff, Monica E. Lemmon, Barbara Scelsa, Brigitte Vollmer, Sarah B. Mulkey, Mark S. Scher, Anthony R. Hart, Eric S. Peeples, Firdose Nakwa, Eleanor Molloy, Andrea C. Pardo, Eleanor Molloy, Eric S. Peeples, Kaashif A. Ahmad, Hany Aly, James P. Boardman, Vann Chau, Gabrielle deVeber, Dawn Gano, Emily M. Herzberg, Lara Leijser, Thiviya Selvanathan, Latha Srinivasan, Courtney J. Wusthoff
Institutions: University of British Columbia, University of California, San Francisco, BC Children's Hospital Research Institute, MRC Centre for Reproductive Health, University of Edinburgh, University of Pennsylvania, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Brown University, Hasbro Children's Hospital, University of Toronto, Hospital for Sick Children, University of California, Davis, Duke University, Ospedale dei Bambini Vittore Buzzi, University Hospital Southampton NHS Foundation Trust, Southampton Children's Hospital, University of Southampton, Children's National, George Washington University, Case Western Reserve University, National Health Service, King's College Hospital NHS Foundation Trust, University of Nebraska Medical Center, University of the Witwatersrand, Trinity College Dublin, Coombe Women & Infants University Hospital, St. James's Hospital, Northwestern University, Woman’s Hospital of Texas, Cleveland Clinic, Sickkids Research Institute, Harvard University, Mass General Brigham, University of Calgary, University College London
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Funder: BC Children's Hospital
OpenAlex ID: W7118390839