State-of-the-Art Review: Transjugular Tricuspid Valve Replacement Using the LuX-Valve Plus System
Year: 2026
Type: article
Abstract: Severe tricuspid regurgitation remains a major therapeutic challenge, particularly in patients with extensive annular dilation or advanced right heart remodeling. Transcatheter tricuspid valve replacement(TTVR) has emerged as a promising alternative for anatomically complex and high‑risk patients who are not suitable for surgery or transcatheter edge‑to‑edge repair. Among currently available systems, the LuX‑Valve Plus device offers a unique transjugular approach and anchoring strategy. This state‑of‑the‑art review provides a comprehensive overview of the LuX‑Valve Plus system, including technical characteristics, procedural steps, multimodality imaging guidance, and key anatomical considerations for patient selection. Drawing on current literature and expert experience, the review describes a step‑by‑step procedural framework with a focus on anatomical screening, computed tomography-based planning, intraprocedural three‑dimensional transesophageal echocardiography, and the use of advanced imaging modalities such as fusion imaging. Practical tips are provided to optimize device positioning, septal anchoring, and leaflet interaction in the setting of highly variable anatomy. Overall, the LuX‑Valve Plus system broadens the spectrum of TTVR to anatomically challenging patients, and this review offers a practical guide for clinicians by offering detailed technical insights, imaging protocols, and procedural strategies essential for successful implantation and avoidance of complications.
Source: Structural Heart
Institutions: Inserm, Centre Hospitalier Universitaire de Rennes, Université de Rennes, Université de Lille, Institut Pasteur de Lille, Centre Hospitalier Universitaire de Lille, Cardiovascular Research Foundation, Université de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, Hôpital Cardiologique du Haut-Lévêque, Centre de Recherche Cardio-Thoracique de Bordeaux, Centre Cardiologique du Nord, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, Albert Einstein College of Medicine, Montefiore Medical Center, Johannes Gutenberg University Mainz, Montreal Heart Institute, University Medical Center of the Johannes Gutenberg University Mainz
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,340
OpenAlex ID: W7118399566