Work

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection

Year: 2026

Type: article

Abstract: Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a chronic infection and disseminate to cutaneous tissues distal to the site of primary infection. This ability is dependent on host immune factors but is also influenced by intrinsic factors of the parasite related to pathogenicity and evasion of the immune system. This review discusses immunological and parasitological factors associated with the latency and dissemination of L. amazonensis infection and the consequent development of severe forms of cutaneous disease.

Source: Parasite Immunology

DOI: 10.1111/pim.70044

Authors: Arieli Bernardo Portugal, Renato Augusto DaMatta, Edézio Ferreira da Cunha Júnior, João Luiz Mendes Wanderley

Institutions: Universidade Federal do Rio de Janeiro, State University of Norte Fluminense

Language: English

Topic: Research on Leishmaniasis Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,220