Click-Enabled Grafting for Adaptive Chiral Recognition in Porous Crystals

Year: 2026

Type: article

Abstract: Reticular frameworks are promising candidates for chiral environments, yet most rely on static stereogenic units, overlooking adaptive host-guest interactions in enantioselective recognition. We report a modular postsynthetic click strategy to install amino acid-derived peptidic moieties into UiO-68 frameworks without compromising crystallinity. Only the histidine-functionalized material exhibits high enantioselectivity for cetirizine. Simulations reveal adaptive interaction pockets, emphasizing the importance of local pore reorganization in chiral molecular recognition.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c17377

Authors: Guillermo Gómez-Tenés, Alechania Misturini, Neyvis Almora-Barrios, Sergio Tatay, Natalia M. Padial, Carlos Martí-Gastaldo

Institution: Universitat de València

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: “la Caixa” Foundation, Ministerio de Ciencia, Innovación y Universidades, European Commission, Generalitat Valenciana, Universitat de València, Universidad de Granada, Agencia Estatal de Investigación, Conselleria d'Educació, Investigació, Cultura i Esport, European Social Fund

OpenAlex ID: W7118417034