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Prostate-specific membrane antigen radioguided surgery in prostate cancer: A narrative review

Year: 2025

Type: review

Abstract: Introduction: Prostate-specific membrane antigen (PSMA) radioguided surgery (RGS) is being tested to personalize lymph node dissection at radical prostatectomy and in the salvage settings. Material and methods: We conducted a narrative review using the MEDLINE database (via PubMed), selecting key publications on the intravenous administration of PSMA to investigate lymph node involvement during surgery. Results: settings, with a median ranging from 93.5% to 100%. However, sensitivity varies widely, with a median range of 50% to 100%, often limited by reduced detection of micrometastases. Detailed preoperative, perioperative, and oncological evaluations are summarized in tables. Conclusions: PSMA-RGS is feasible and safe in both primary and salvage settings. In appropriately selected patients, it may contribute to longer therapy-free survival (36 months) and prolonged biochemical recurrence-free survival (19 months).

Source: Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication

DOI: 10.5173/ceju.2025.0121

Authors: Piotr Chuchra, Jakub Karwacki, Akihiro Matsukawa, Bartłomiej Borek, Tomasz Rynkiewicz, Omar Tayara, Bartosz Małkiewicz, Paweł Rajwa, Andrzej Paradysz, Marcin Zyczkowski

Institutions: Medical University of Silesia, University of Wrocław, Wroclaw Medical University, Jikei University School of Medicine, Comprehensive Cancer Center Vienna, Medical University of Vienna, University of Opole

Language: English

Topic: Prostate Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7118419403

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