Comparison of the performance of different formulae to assess eGFR in children after allogenic hematopoietic stem cell transplantation
Year: 2025
Type: article
Abstract: Introduction: There is an ongoing debate concerning the right formula to estimate GFR in pediatric oncological patients or recipients of hematopoietic stem cell transplantation. Material and methods: Schwartz equation 2009 (Schwartz 2009), Flanders Metadata (FLANDERS), CKiD U25 Creatinine (U25CREA), and CKiD U25 Cystatin C (U25CYSC) against Creatinine-Cystatin C-Urea-based CKiD Equation (Schwartz Combined 2012) as the reference. Results: , respectively). The root mean square error was lowest for FLANDERS (26.9) and highest for U25CYSC (32.36). Both 30% and 10% accuracy was highest for FLANDERS (91.06 and 42.46%, respectively), and lowest for U25CYSC (78.77 and 31.28%, respectively). Conclusions: There were small differences in accuracy between simpler eGFR formulae against the reference formula, however we observed differences in error. The U25CYSC offered best accuracy but largest error leading to underestimation of eGFR. Therefore, when applying given formula, one must be mindful of its potential limitations and potential inherent biases.
Authors: Katarzyna Gąsowska, Katarzyna Zachwieja, Jolanta Goździk, Dorota Drożdż
Institutions: Jagiellonian University, Uniwersytecki Szpital Dziecięcy
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7118488303
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