Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure
Year: 2026
Type: article
Abstract: Sarcopenia in alcohol-related liver disease (ALD) is frequent and contributes to adverse clinical outcomes with limited treatment options. Hyaluronans (glycosaminoglycan polymers) of specific fragment sizes (30-40 kDa) have anti-inflammatory and tissue-protective properties. In an array of preclinical models of ALD, we demonstrate that HA35 reverses signaling, mitochondrial oxidative function, and phenotypic perturbations associated with sarcopenia in ALD. These effects are mediated without restoring the low muscle tissue concentrations of HA in ALD.
Authors: Nicole Welch, Pugazhendhi Kannan, Gangarao Davuluri, Annette Bellar, Amy H. Attaway, Saurabh Mishra, Jasmin A. Cunningham, Avinash Kumar, Ryan Musich, Elif G. Ertugral, Vandana Agrawal, Isaac L. Hsu, Terri J. Harford, Noah L. Weisleder, Vidula T. Vachharajani, Chandrasekhar R. Kothapalli, Carol A. de la Motte, Laura E. Nagy, Srinivasan Dasarathy
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: MRI: Acquisition of an integrated atomic force microscope/ Inverted optical microscope for interdisciplinary research at Cleveland State University, G9000023348, G9000075553, G9000169431, G9000190944, G9000210377, G9000247975, Nocturnal hypoxemia dysregulates skeletal muscle protein homeostasis in COPD
OpenAlex ID: W7118501931
FWCI:
Cites:
Cited by:
Related to: