Work

Unraveling the microbial landscape in prostate cancer: pathogenesis to therapy

Year: 2026

Type: article

Abstract: Emerging evidence suggests a role of microbiota in prostate cancer, yet this association remains poorly understood. This review systematically examines microbes from the skin, oral cavity, gut, urinary tract, and the prostate cancer microenvironment, summarizing how these communities affect prostate cancer initiation, progression, and therapeutic response. We highlight key molecular pathways and metabolic reprogramming events underlying host-microbiota interactions and outline current findings and knowledge gaps to guide microorganism-based therapeutic strategies.

Source: npj Biofilms and Microbiomes

DOI: 10.1038/s41522-025-00900-w

Authors: Xiancai Du, Jing Wu, Siyuan Xia, Hao Zheng, Baotong Zhang

Institutions: Southern University of Science and Technology, China Agricultural University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,290