Work

Primary Large Cell Neuroendocrine Carcinoma of the Prostate Gland: An Uncommon Case

Year: 2025

Type: article

Abstract: Primary large cell neuroendocrine prostate cancer is a rare and aggressive cancer commonly observed as a transformation of an already known prostate adenocarcinoma and on long-term androgen deprivation, although it can arise de novo. It has high potential for distant metastatic spread and is generally associated with poor survival compared to the classical adenocarcinoma type of prostate cancer. We present a case of an 83-year-old who had orchidectomy for treatment of metastatic prostate adenocarcinoma with normalization of prostate-specific antigen levels and subsequently developed recurrence with large cell neuroendocrine transformation.

Source: World Journal of Nuclear Medicine

DOI: 10.1055/s-0045-1813677

Authors: Margaret M. Mwania, Dayib Buthul, Samuel Nguku, Khalid Makhdomi

Institutions: Aga Khan University Hospital Nairobi, Aga Khan University Nairobi

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7118603333