Work

Aloin attenuates NMDA receptor by modulating calcium response on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice

Year: 2026

Type: article

Abstract: influx but occurred independently of voltage-gated sodium channels and action potential generation. Calcium imaging revealed that aloin reduced NMDA-induced intracellular calcium influx, supporting its role in mitigating NMDA-mediated excitotoxicity. Furthermore, aloin significantly suppressed the spontaneous firing activity of SG neurons, suggesting its broader regulatory effects on neuronal excitability. Our findings demonstrate that aloin attenuates NMDA receptor-induced excitatory signaling by regulating calcium response. This specificity highlights aloin's potential as a therapeutic candidate for conditions involving glutamate excitotoxicity and orofacial pain regulation.

Source: Korean Journal of Physiology and Pharmacology

DOI: 10.4196/kjpp.25.317

Authors: Thi Quynh Nhu Tran, Seon Ah Park, Seon Hui Jang, Won Jung, Seong Kyu Han

Institutions: Huế University of Medicine and Pharmacy, Jeonbuk National University, Jeonbuk National University Hospital

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Biomedical Research Institute, Jeonbuk National University Hospital, Ministry of Education, Jeonbuk National University