Work

Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited

Year: 2026

Type: article

Abstract: The therapeutic potential of PARP inhibitors in neurodegenerative diseases of the central nervous system is widely accepted. This prevailing concept is challenged by more recent findings, unveiling the role of PARP1 activity in synaptic long-term potentiation, synaptic plasticity and long-term memory. So, PARP1 inhibition, though intended to prevent memory deterioration, actually interferes with stimulation-induced synaptic plasticity and long-term memory. On the other hand, PARP inhibitors could be useful for preventing mental disorders associated with memory retrieval.

Source: Molecular Psychiatry

DOI: 10.1038/s41380-025-03426-x

Authors: Malka Cohen-Armon, Menahem Segal

Institutions: Tel Aviv University, Weizmann Institute of Science

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,490