Work

A Case Report of Acute Lymphoblastic Leukemia Presenting as Bilateral Knee Pain in a Healthy Runner

Year: 2026

Type: article

Abstract: INTRODUCTION: Acute lymphoblastic leukemia (ALL) is typically a childhood disease but may present in older patients in rare occurrences. Due to its significant morbidity and mortality, early diagnosis is crucial. The symptoms of ALL may be non-specific, making the initial diagnosis difficult leading to delayed treatment. CASE REPORT: We present the case of a 34-year-old, healthy male runner presenting to the emergency department with a common complaint of bilateral knee pain, who was ultimately diagnosed with ALL with signs of tumor lysis syndrome leading to premature death. CONCLUSION: We discuss the presenting symptoms of acute lymphoblastic leukemia, which may include joint or knee pain as well as leukemic arthritis. We further discuss the importance of clinicians maintaining a high level of suspicion for the "bounce-back" patient and avoiding taking cognitive shortcuts.

Source: Clinical Practice and Cases in Emergency Medicine

DOI: 10.5811/cpcem.47307

Authors: Michael Rosselli, Alejandro Jesus Sanoja, Matthew Apicella

Institutions: Mount Sinai Medical Center, University of Florida Health, University of Florida

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $500